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At the start of the pandemic, the Ontario Government chose Calian to administer the COVID-19 vaccine to Indigenous community members and residents of First Nations elder care homes in 31 fly-in northern locations. Indigenous Services Canada also selected Calian to provide COVID-19 screening and paramedic services to several Indigenous communities.

From September 2021 to May 2022, the Calian Emergency Management team developed a back-to-work action plan for the Mississaugas of Scugog Island First Nation (MSIFN) to guide a safe return to work after the COVID-19 pandemic shutdown. The plan provided structure and guidance for a scalable resumption of operations and a safe return of staff in a COVID-19 environment. The Weeneebayko Area Health Authority also engaged Calian to provide vaccination services to remote communities along the James Bay and Hudson Bay coasts in Northern Ontario.

Calian Health deployed nurses to support the pandemic response in Nunavut and provided COVID-19 screening, quarantine management, testing and mental health support in isolation sites in Yellowknife, Edmonton, Winnipeg, Ottawa and Quebec City. The team of Calian nurses also supported the 25 communities in Nunavut through mass vaccination programs, flying to remote and isolated communities to administer vaccines to the residents.

The Government of Nunavut implemented virtual public health services in April 2020 to support the work being performed by public health teams and community health centres. These services involved both virtual public health nurse (VPHN) and hotline services. In June 2021, Calian signed a three-year contract extension to continue the delivery of COVID-19 virtual nursing services. The Calian team has delivered more than 110,000 doses of COVID-19 vaccines to Nunavut and 68.7 per cent of these doses have been administered.